Investigation of Pulmonary Physiological Compensatory Mechanism with Hyperpolarized 129Xe MR
Xiaoling Liu1, Haidong Li1, Hongchuang Li1, Ming Zhang1, Xiuchao Zhao1, Yu Zheng1, Ming Luo1, Yecheng Li1, Xianping Sun1, Yeqing Han1, Chaohui Ye1, and Xin Zhou1
1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences- Wuhan National Laboratory for Optoelectronics, Wuhan, China
In this study, we tried to use hyperpolarized (HP) 129Xe MR to explore pulmonary physiological compensatory mechanisms. With the increased Xe washout times, obvious changes of chemical shift, FWHM, RBC oscillation amplitude and the parameters extracted from MOXE model could be found. Our study demonstrates the feasibility of HP 129Xe MR for assessing pulmonary compensatory capacity, which would be helpful for understanding lung function changes caused by pulmonary diseases and early diagnosis.
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