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Abstract #4675

Evidence for nigral neuromelanin abnormalities in rat brain in the methamphetamine addiction assessed by neuromelanin-sensitive MRI

Fei Tang1, Jun Liu1, Yongming Dai2, Liyun Zheng2, Xiaojie Zhang1, Huihui Zheng1, Wenhan Yang1, and Yanyao Du1
1The Second Xiangya Hospital of Central South University, Changsha, China, 2MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China


NM-MRI is a newly developed magnetic resonance imaging technique, which indirectly measures dopamine synthesis and demonstrate neuromelanin-related contrast. In this study, ten rats with acute methamphetamine exposure underwent a NM-MRI scan at different time points. The NM-MRI data of four brain regions were measured and compared. The results showed significantly higher NM-MRI signal in substantia nigra compared to other brain regions, and the NM-MRI signal gradually increased over time in almost all measured brain regions. These findings demonstrated the potential of NM-MRI as biomarker and the predictive value of NM-MRI for dopamine function.

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