Abstract #4675

Evidence for nigral neuromelanin abnormalities in rat brain in the methamphetamine addiction assessed by neuromelanin-sensitive MRI

Fei Tang¹, Jun Liu¹, Yongming Dai², Liyun Zheng², Xiaojie Zhang¹, Huihui Zheng¹, Wenhan Yang¹, and Yanyao Du¹

¹The Second Xiangya Hospital of Central South University, Changsha, China, ²MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

NM-MRI is a newly developed magnetic resonance imaging technique, which indirectly measures dopamine synthesis and demonstrate neuromelanin-related contrast. In this study, ten rats with acute methamphetamine exposure underwent a NM-MRI scan at different time points. The NM-MRI data of four brain regions were measured and compared. The results showed significantly higher NM-MRI signal in substantia nigra compared to other brain regions, and the NM-MRI signal gradually increased over time in almost all measured brain regions. These findings demonstrated the potential of NM-MRI as biomarker and the predictive value of NM-MRI for dopamine function.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.