NM-MRI is a newly developed magnetic resonance imaging technique, which indirectly measures dopamine synthesis and demonstrate neuromelanin-related contrast. In this study, ten rats with acute methamphetamine exposure underwent a NM-MRI scan at different time points. The NM-MRI data of four brain regions were measured and compared. The results showed significantly higher NM-MRI signal in substantia nigra compared to other brain regions, and the NM-MRI signal gradually increased over time in almost all measured brain regions. These findings demonstrated the potential of NM-MRI as biomarker and the predictive value of NM-MRI for dopamine function.
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