Abstract #4676

Longitudinal dynamic changes in DTI metrics after repetitive mild traumatic brain injury with different intervals

Ching Cheng¹, Chia-Feng Lu¹, Bao-Yu Hsieh², and Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming Chiao-Tung University, Taipei, Taiwan, ²Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan

Synopsis

Long-term effects of repetitive mild traumatic brain injury (rmTBI) with the short versus long interinjury interval were explored using quantitative DTI and immunohistological staining. Significant changes in DTI metrics under the impact site and the lateral part of white matter in the ipsilesional brain after rmTBI may suggest the exacerbated microstructural damage induced by repetitive injury with the short interval.

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