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Abstract #4677

HPA hyperactivity leads to time dependent alterations in serum metabolomics and inflammatory profile of closed head injured rats

Palkin Arora1, Richa Trivedi1, Kavita Singh1,2, and Megha Kumari1
1RNAIS, INMAS-DRDO, New Delhi, India, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States


Closed head injury (CHI) can lead to both neurological disabilities and systemic alterations through HPA axis activation. A dysregulated HPA function allows relocation of energy substrates and alterations in metabolic pathways and systemic inflammation. Assessment of time-dependent changes in serum metabolites and inflammatory markers showed unique pattern between mild and moderate injured rats. These alterations were found to be associated with HPA hyperactivity with increased serum corticosterone levels and hypothalamic microglial activation post mild and moderate TBI. The study suggests an important relation between HPA axis induced changes in systemic metabolomics.

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