The present study revealed a correlation of metabolic activity of intestinal mucosa with enzymatic, secretory, and functional activity in patients with celiac disease (CeD). Significantly lower concentrations of choline, GPC, and histidine were observed patients along with the significantly lower expression of villin in both villi and crypt of the CeD compared to disease controls (DC) controls. Higher expression of Mucin 3 in the crypt of the CeD was seen. A significant correlation between expression of villin, mucin and metabolites GPC and histidine provided an insight into underlying biochemical and functional mechanism of mucosal damage in CeD.
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