Abstract #4678

Correlation of metabolomics of intestinal mucosal biopsies with enzyme and secretory activity of duodenal enterocytes in celiac disease

Uma Sharma¹, Deepti Upadhyay¹, Ritu Tyagi¹, Prasenjit Das², and Govind Makharia³

¹Department of NMR, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ²Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ³Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Synopsis

The present study revealed a correlation of metabolic activity of intestinal mucosa with enzymatic, secretory, and functional activity in patients with celiac disease (CeD). Significantly lower concentrations of choline, GPC, and histidine were observed patients along with the significantly lower expression of villin in both villi and crypt of the CeD compared to disease controls (DC) controls. Higher expression of Mucin 3 in the crypt of the CeD was seen. A significant correlation between expression of villin, mucin and metabolites GPC and histidine provided an insight into underlying biochemical and functional mechanism of mucosal damage in CeD.

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