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Abstract #4733

The Development of Hollow Gd2O3 Nanospheres for T1 Contrast Agent

Hongyun Li1, Zhenxiong Wang2, Zhongping Zhang3, and Jie Fang1
1Nantong University, Nantong, China, 2Guangzhou First People's Hospital, Guangzhou, China, 3Philips Healthcare China, Guangzhou, China


Gd2O3 hollow nanospheres (HNS) with tuneable size and shell thickness was prepared. The thinnest shell of 30 nm Gd2O3 HNS achieved is 2.9 nm. This ultra-thin Gd2O3 HNS show effective T1 relaxivity in MRI with the highest r1 value of 3.77 mM-1s-1. Furthermore, the Gd2O3 HNS indicate strong chemical and physical stability which will minimize the toxicity caused by released free Gd3+ ions. The monodispersed and tuneable particle size will also facilitate the particle surface modification and blood circulation time design in bio-applications.

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