Diffusion-weighted imaging (DWI) near metal remains a technical challenge although several 3D multispectral imaging methods have achieved effective metallic artifacts correction in anatomical MRI. Additionally, considering scan time and scan flexibility, 2D multi-slice acquisition approaches are typically used in DWI. In this study, we adopted 2D Point-Spread-Function Encoded EPI to generate a series of echo-shifted in-plane distortion-corrected images and introduced an off-resonance frequency-informed reconstruction framework to further reduce metallic artifacts in DWI by through-slice signal registration. The efficacy of this method was validated in phantom experiments, in-vivo brain DTI and spinal cord DWI.
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