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Abstract #4750

Discriminating Rectal Cancer Grades using Restriction Spectrum Imaging

Zhongyan Xiong1, Zhijun Geng2, Shanshan Lian2, Shaohan Yin2, Guixiao Xu2, Yunfei Zhang3, Yongming Dai3, Jing Zhao2, Lidi Ma2, Xin Liu1, Hairong Zheng1, Chuanmiao Xie2, and Chao Zou1
1Paul C. Lauterbur Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou, China, 3Central Research Institute, United Imaging Healthcare, Shanghai, China


Restriction spectrum imaging (RSI) is a novel diffusion model that captures the distinct diffusion behavior of tumors. It separates water diffusion into several microscopic compartments. The restricted compartment correlating to the tumor cellularity is expected to be a potential indicator of rectal cancer aggressiveness. To assess the ability of RSI model for rectal tumor grading, we applied a three-compartment RSI model to DWI images of patients with different histopathological grades of rectal cancer. The RSI model demonstrated its ability to discriminate the rectal cancer of low and high grades, and the results outperforms the traditional ADC model and DKI model.

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