Abstract #4749

Investigating the dot-compartment using diffusion MRI line scanning

Viktor Vegh^1,2, Thomas Barrick³, Qianqian Yang⁴, Qiang Yu¹, and Martijn Cloos^1,2

¹Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ²ARC Training Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia, ³Neuroscience Research Centre, St George's, University of London, London, United Kingdom, ⁴School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia

Synopsis

Diffusion MRI provides opportunities in probing tissue microstructure based on mm-scale measurements. Generally, an MRI diffusion model is used to infer biologically meaningful information from diffusion MRI measurements. Recently, there has been increasing interest in mapping the so-called dot-compartment in the human brain. The dot-compartment has been ascribed to a tissue compartment which has highly restricted diffusion. Using a custom diffusion MRI line scan we investigated the ability to obtain high b-value signals using 3T MRI equipped with 80mT/m gradients. It appears that the dot-compartment is elusive when probed using clinical standard scanners even when b-values of 15000s/mm² are achieved.

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