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Abstract #4749

Investigating the dot-compartment using diffusion MRI line scanning

Viktor Vegh1,2, Thomas Barrick3, Qianqian Yang4, Qiang Yu1, and Martijn Cloos1,2
1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, 2ARC Training Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia, 3Neuroscience Research Centre, St George's, University of London, London, United Kingdom, 4School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia


Diffusion MRI provides opportunities in probing tissue microstructure based on mm-scale measurements. Generally, an MRI diffusion model is used to infer biologically meaningful information from diffusion MRI measurements. Recently, there has been increasing interest in mapping the so-called dot-compartment in the human brain. The dot-compartment has been ascribed to a tissue compartment which has highly restricted diffusion. Using a custom diffusion MRI line scan we investigated the ability to obtain high b-value signals using 3T MRI equipped with 80mT/m gradients. It appears that the dot-compartment is elusive when probed using clinical standard scanners even when b-values of 15000s/mm2 are achieved.

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