Abstract #4761
Quantitative anisotropy-based fiber tractography reveals tracts moderating age-related decline in functional fitness
Paul B Camacho1,2,3,4, Nishant Bhamidipati1,5, Emily Erlenbach6, Veronica Garcia6, Edward McAuley1,6, Nicholas Burd6, Jessica Damoiseaux7,8, Brad P Sutton1,2,5, and Neha P Gothe1,6
1Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Interdisciplinary Health Sciences Institute, University of Illinois at Urbana Champaign, Urbana, IL, United States, 4Carle-Illinois Advanced Imaging Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 7Institute of Gerontology, Wayne State University, Detroit, MI, United States, 8Psychology, Wayne State University, Detroit, MI, United States
Synopsis
We present a moderation analysis of the effects of edge strengths from generalized q-sampling imaging-based tractography on the relationship between age and decline in functional fitness in older adults (n = 105, ages 55-79 years old, right-handed). The results of these moderation analyses suggest that the strengths of white matter structural connections involving the cerebellum, cingulum, and other areas involved in motor, sensory, and environmental perception may play a significant role in preserving functional fitness in older adults.
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