Abstract #4761

Quantitative anisotropy-based fiber tractography reveals tracts moderating age-related decline in functional fitness

Paul B Camacho^1,2,3,4, Nishant Bhamidipati^1,5, Emily Erlenbach⁶, Veronica Garcia⁶, Edward McAuley^1,6, Nicholas Burd⁶, Jessica Damoiseaux^7,8, Brad P Sutton^1,2,5, and Neha P Gothe^1,6

¹Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Interdisciplinary Health Sciences Institute, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Carle-Illinois Advanced Imaging Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁷Institute of Gerontology, Wayne State University, Detroit, MI, United States, ⁸Psychology, Wayne State University, Detroit, MI, United States

Synopsis

We present a moderation analysis of the effects of edge strengths from generalized q-sampling imaging-based tractography on the relationship between age and decline in functional fitness in older adults (n = 105, ages 55-79 years old, right-handed). The results of these moderation analyses suggest that the strengths of white matter structural connections involving the cerebellum, cingulum, and other areas involved in motor, sensory, and environmental perception may play a significant role in preserving functional fitness in older adults.

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