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Abstract #4764

High dynamicity of cortical depth-dependent connectivity states

Patricia Pais-Roldan1, Shukti Ramkiran1,2, Seong Dae Yun1, and Jon N. Shah1,3,4,5
1INM-4, Forschungszentrum Juelich, Juelich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3INM-11, Forschungszentrum Juelich, Juelich, Germany, 4Translational Medicine, JARA-BRAIN, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany


We assessed resting-state fMRI acquired with high spatial resolution with a dynamic functional connectivity analysis involving multiple cortical ROIs and depths. Two states relevant to the normalized global laminar connectivity were identified in healthy volunteers (superficial vs. deep layer connectivity predominance). Mean laminar connectivity states were much more dynamic than the states identified in a routine ROI-based dynamic connectivity analysis, suggesting the potential of high-spatial-resolution fMRI to reveal time-varying features in the human brain.

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