Functional connectome of hypothalamus, nucleus accumbens and hippocampus in living humans from 7 Tesla resting-state fMRI
Simone Cauzzo1,2,3, Maria Guadalupe Garcia Gomar3,4, Kavita Singh3, and Marta Bianciardi3,5
1Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy, 2Research Center E. Piaggio, University of Pisa, Pisa, Italy, 3Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging (MGH), Charlestown, MA, United States, 4Escuela Nacional de Estudios Superiores, Juriquilla, Universidad Nacional Autónoma de México, Queretaro, Mexico, 5Division of Sleep Medicine, Harvard University, Boston, MA, United States
The hypothalamus and nucleus accumbens promote respectively wakeful arousal and sleep, producing a stable cycle between states. The hippocampus is inherently connected to this cycle, which modulates memory encoding during wakefulness and sleep. While their connectivity to cortical regions is detailed in literature, their connectivity with brainstem nuclei is understudied in living humans.
By using high spatial resolution 7 Tesla resting state fMRI and an in-vivo brainstem nuclei atlas, we provided a functional connectome of hypothalamus, nucleus accumbens and hippocampus with the rest of the brain, including 58 brainstem nuclei along with 148 cortical and 25 subcortical structures.
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