The hypothalamus and nucleus accumbens promote respectively wakeful arousal and sleep, producing a stable cycle between states. The hippocampus is inherently connected to this cycle, which modulates memory encoding during wakefulness and sleep. While their connectivity to cortical regions is detailed in literature, their connectivity with brainstem nuclei is understudied in living humans.
By using high spatial resolution 7 Tesla resting state fMRI and an in-vivo brainstem nuclei atlas, we provided a functional connectome of hypothalamus, nucleus accumbens and hippocampus with the rest of the brain, including 58 brainstem nuclei along with 148 cortical and 25 subcortical structures.
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