Traumatic brain injury (TBI) can lead to dynamic changes in functional network activity that can be assessed by functional magnetic resonance imaging (fMRI). In this study, we utilized a novel temporal correlation analysis approach to evaluate a novel microbiome transplantation treatment effect on network connectivity in a translational porcine. Sparse dictionary learning (sDL) and independent component analysis (ICA) were applied to both a full dataset (TBI and sham) and the Sham-only dataset, resulting in four groups of results. Consistency was observed across the four results, indicating that evaluation of treatment effects can be achieved through the proposed temporal correlation analysis.
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