Dixon Magnetic Resonance Fingerprinting (Dixon-MRF) is being increasingly used to measure multiple quantitative parameters with effective fat suppression across body tissues. Dixon-MRF processing is typically performed in two steps: water-fat separation and dictionary matching. The present work introduces a versatile formulation for chemical species separation in Dixon-MRF (CSS-MRF) which allows to process a multi-echo fingerprint in a single step obtaining a water fingerprint, a fat fingerprint, a B0 value and a R2* value as outputs. CSS-MRF allows an easy and flexible definition of the parameters to be estimated and enables the option of a varying fat spectrum across the MRF-dimension.
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