Abstract #4799

Whole-brain high-resolution MRSI at 7T with non-Cartesian FID-ECCENTRIC in glioma patients

Antoine Klauser^1,2, Bernhard Strasser³, Wolfgang Bogner³, Lukas Hingerl³, Claudiu Schirda⁴, Bijaya Thapa⁵, Daniel Cahill⁶, Tracy Batchelor⁷, Francois Lazeyras¹, and Ovidiu Andronesi⁵

¹University of Geneva, Geneva, Switzerland, ²CIBM Center for Biomedical Imaging, Geneva, Switzerland, ³Medical University of Vienna, Vienna, Austria, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ⁶Massachusetts General Hospital, Boston, MA, United States, ⁷Brigham and Women Hospital, Boston, Switzerland

Synopsis

MR spectroscopic imaging (MRSI) can map specific metabolic alterations of glioma brain tumors. Increasing structural details for spatial distribution of metabolites is needed to probe tumor margins and heterogeneity with higher sensitivity and specificity. Here we evaluate the performance of ECCENTRIC, a newly developed non-Cartesian compressed sense MRSI method, to realize fast and high-resolution metabolic imaging at 7T ultra-high field in glioma patients. This is expected to improve diagnosis, prognostication, planning, guidance, and response assessment of treatment in glioma patients and other brain diseases.

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