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Abstract #4799

Whole-brain high-resolution MRSI at 7T with non-Cartesian FID-ECCENTRIC in glioma patients

Antoine Klauser1,2, Bernhard Strasser3, Wolfgang Bogner3, Lukas Hingerl3, Claudiu Schirda4, Bijaya Thapa5, Daniel Cahill6, Tracy Batchelor7, Francois Lazeyras1, and Ovidiu Andronesi5
1University of Geneva, Geneva, Switzerland, 2CIBM Center for Biomedical Imaging, Geneva, Switzerland, 3Medical University of Vienna, Vienna, Austria, 4University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 6Massachusetts General Hospital, Boston, MA, United States, 7Brigham and Women Hospital, Boston, Switzerland


MR spectroscopic imaging (MRSI) can map specific metabolic alterations of glioma brain tumors. Increasing structural details for spatial distribution of metabolites is needed to probe tumor margins and heterogeneity with higher sensitivity and specificity. Here we evaluate the performance of ECCENTRIC, a newly developed non-Cartesian compressed sense MRSI method, to realize fast and high-resolution metabolic imaging at 7T ultra-high field in glioma patients. This is expected to improve diagnosis, prognostication, planning, guidance, and response assessment of treatment in glioma patients and other brain diseases.

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