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Abstract #4800

Fast adiabatic spin-echo with whole-brain ECCENTRIC for glioma metabolic imaging at 7T

Antoine Klauser1,2, Bernhard Strasser3, Wolfgang Bogner3, Bijaya Thapa4, Jorg Dietrich5, Erik Uhlmann5, Tracy Batchelor6, Daniel Cahill5, Francois Lazeyras1,2, and Ovidiu Andronesi4
1University of Geneva, Geneva, Switzerland, 2CIBM Center for Biomedical Imaging, Geneva, Switzerland, 3Medical University of Vienna, Vienna, Austria, 4Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 5Massachusetts General Hospital, Boston, MA, United States, 6Brigham and Women Hospital, Boston, MA, United States


Metabolic alterations specific to glioma can be imaged by MR spectroscopic imaging (MRSI). Adiabatic spin-echo (ASE) MRSI enables spectral editing for specific metabolites with uniform excitation over whole-brain but needs long TR at 7T due to specific absorption rate which results in long acquisition times for high spatial resolution. Acceleration of ASE can be obtained with non-cartesian compressed sense MRSI (ECCENTRIC) acquisition. Here we evaluate the performance of ASE-ECCENTRIC metabolic imaging in glioma patients. We expect that enhanced spectral sensitivity, specificity and high spatial resolution of ASE-ECCENTRIC will improve diagnosis, prognostication, and treatment response monitoring in glioma patients.

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