Abstract #4836

Improvement of Accuracy and Stability of Oxygen Extraction Fraction Measurements by Using Triple-Echo Asymmetric Spin Echo Sequence

Jian Shen¹ and John Wood^1,2

¹University of Southern California, Los Angeles, CA, United States, ²Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

Synopsis

Asymmetric Spin Echo (ASE) is a popular technique to obtain quantitative estimates of R₂’, cerebral venous blood volume (vCBV), and oxygen extraction fraction (OEF) noninvasively in normal subjects. In this study, We demonstrated the feasibility of using Triple-Echo ASE to induce a more stable and accurate vCBV and OEF estimates with no increase in scan time. In addition, this study investigated the role of diffusion in ASE measurements and provided insights into future acquisition approaches.

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