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Abstract #4837

Surface-Volume Registration Produces Atlases More Realistic than Either Surface or Volume Registration

Sahar Ahmad1, Zhengwang Wu1, Weili Lin1, Gang Li1, Li Wang1, and Pew-Thian Yap1
1Department of Radiology and Biomedical Research Imaging Center (BRIC), The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States


We show that spatial registration by simultaneously considering both tissue contrast and cortical geometry produces brain atlases that are more reflective of individuals than registration by considering only one of the two factors alone. Registration with tissue contrast alone produces atlases with blurred cortical structures. Registration with cortical geometry alone produces surface atlases that are artificially sharp but do not reflect surface attributes of individuals.

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