Abstract #4838
Pathway analysis of cerebral bicarbonate production from hyperpolarized [1-13C]pyruvate
Maheen Zaidi1,2,3, Jun Chen1, Junjie Ma1, Xiaodong Wen1, Brenda Bartnik-Olson4, and Jae Mo Park1,5,6
1Advanced Imaging Research Center, UT Southwestern, Dallas, TX, United States, 2Psychology, UT Dallas, Richardson, TX, United States, 3Neurobiology, UT Dallas, Richardson, TX, United States, 4Radiology, Loma Linda University, Loma Linda, CA, United States, 5Radiology, UT Southwestern, Dallas, TX, United States, 6Electrical Engineering, UT Dallas, Richardson, TX, United States
Synopsis
Detection of [13C]bicarbonate in the brain from hyperpolarized [1-13C]pyruvate provides a unique opportunity for assessing cerebral mitochondrial function in-vivo. Although decarboxylation of the labeled pyruvate occurs within the mitochondria, the metabolic path of the injected pyruvate could be complex before being transported to intracellular space. In this study, we investigated the likelihood of pyruvate being converted to lactate prior to decarboxylation.
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