Abstract #4839
Assessment of human brain pyruvate oxidation using functional hyperpolarized 13C MRS
Maheen Zaidi1,2,3, Binu P. Thomas1,4, Junjie Ma1, Salvador Pena1, Jun Chen1, James Ratnaker1, Craig R. Malloy1,4,5, Brenda Bartnik-Olson6, and Jae Mo Park1,4,7
1Advanced Imaging Research Center, UT Southwestern, Dallas, TX, United States, 2Psychology, UT Dallas, Richardson, TX, United States, 3Neurobiology, UT Dallas, Richardson, TX, United States, 4Radiology, UT Southwestern, Dallas, TX, United States, 5Internal Medicine, UT Southwestern, Dallas, TX, United States, 6Radiology, Loma Linda University, Loma Linda, CA, United States, 7Electrical and Computer Engineering, UT Dallas, Richardson, TX, United States
Synopsis
[13C]Bicarbonate production from hyperpolarized [1-13C]pyruvate in the brain is directly related to pyruvate oxidation and, thus serves a potential biomarker of brain function. In this study, we assessed time-wise bicarbonate production in the visual cortex during activation with minimal perturbation of its precursors, pyruvate and lactate, using a multichannel 13C receive array, a spectral-spatial RF pulse that fully excites bicarbonate signals, and dynamic 13C MRS. The real-time changes of bicarbonate production in response to visual stimuli were observed in healthy volunteers.
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