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Abstract #4840

Differentiating TCA Cycle Activity of Gray and White Matter in Human Brain at 7T Using High Resolution Dynamic Deuterium MRS Imaging with SPICE

Xiao-Hong Zhu1, Hannes M Wiesner1, Yudu Li2,3, Wei Zhu1, Tao Wang1, Xin Li1, Zhi-Pei Liang2,3, and Wei Chen1
1University of Minnesota, Minneapolis, MN, United States, 2Beckman Institute for Advanced Science and Technology, Urbana, IL, United States, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States


The emerging deuterium MRS (DMRS) imaging (DMRSI) technology has shown great promise in studying brain glucose metabolism, TCA cycle and glycolytic activity. In particular, its potential as a clinical tool for tumor detection in brain or other organs has attracted a lot of attention. However, the temporal and spatial resolution of dynamic DMRSI is limited by its low detection sensitivity. In this study, we proved that 7T high-resolution dynamic DMRSI combined with SPICE method can not only map the Glx production rate constant, but also distinguish the TCA cycle activity level between human brain gray matter and white matter.

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