The emerging deuterium MRS (DMRS) imaging (DMRSI) technology has shown great promise in studying brain glucose metabolism, TCA cycle and glycolytic activity. In particular, its potential as a clinical tool for tumor detection in brain or other organs has attracted a lot of attention. However, the temporal and spatial resolution of dynamic DMRSI is limited by its low detection sensitivity. In this study, we proved that 7T high-resolution dynamic DMRSI combined with SPICE method can not only map the Glx production rate constant, but also distinguish the TCA cycle activity level between human brain gray matter and white matter.
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