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Abstract #4852

Is T2 a biomarker of inflammation in normal appearing gray matter: Maybe!

Qandeel Shafqat1, Rehman Tariq1, Rania Muhammed1, Ying Wu1, and Jeff F. Dunn1
1Department of Radiology, University of Calgary, Calgary, AB, Canada


With the reduction in use of gadolinium enhanced MRI for assessment of neuroinflammation, it is important to identify new non-invasive biomarkers of brain inflammation, as well as to understand the link between inflammation induced pathology and MRI. We used quantitative T2, behaviour and histology to study gray matter in an LPS mouse model of inflammation. There was a significant reduction in T2, along with behaviour and histological markers indicating inflammation. Although T2 appears useful as biomarker for inflammation, it may be that the precision needed will make it difficult to implement in patients.

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