Morphological changes in the pituitary gland and brain stiffness in idiopathic intracranial hypertension (IIH) are not well understood. We evaluated the difference in pituitary height and regional brain stiffness between IIH patients and controls and how these metrics change following acute and chronic treatment. The pituitary gland is smaller in IIH patients than controls and increases in size after chronic, but not acute, treatment of raised intracranial pressure. IIH patients have a different pattern of brain stiffness than controls, including stiffer occipital lobes. Following chronic treatment, the stiffness pattern becomes more like controls, though occipital stiffness does not significantly change.
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