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Abstract #4856

Increased hippocampal cerebrospinal fluid fraction is associated with episodic verbal learning and memory deficits in multiple sclerosis

Thanh D Nguyen1, Liangdong Zhou1, Elizabeth M Sweeney1, Melanie Marcille1, Susan A Gauthier1, Yi Wang1, and Yi Li1
1Weill Cornell Medicine, New York, NY, United States


We applied FAST-T2 multi-component T2 relaxometry to 145 MS patients and found that the mean hippocampal CSF fraction, a measure of glymphatic clearance dysfunction in the hippocampus, was negatively associated with verbal learning and memory performance measured by the California Verbal Learning Test after adjusting for age, sex, MS phenotype, disease duration, and log total lesion volume.

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