Abstract #4857

A Multi-Sequence, Interleaved MRI-DMI Protocol for Human Brain

Yanning Liu¹, Henk M De Feyter², Robert K Fulbright², Scott McIntyre², Terence W Nixon², and Robin A de Graaf^1,2

¹Department of Biomedical Engneering, Yale University, New Haven, CT, United States, ²Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Synopsis

Deuterium Metabolic Imaging (DMI) is an emerging method to spatially map metabolism in vivo. To enhance the time efficiency of a combined MRI-DMI protocol, interleaved MRI-DMI acquisitions were developed for multiple clinical MRI sequences. The protocol includes four MRIs that are commonly used in neurological MRI exams, namely FLAIR, T₂W, SWI and T₁W MP-RAGE, with DMI acquisition in parallel, acquired in 28 minutes. We demonstrate the performance of the interleaved MRI-DMI protocol on healthy human brain and discuss the guiding principles as well as limitations of extending other MRI sequences with DMI using the presented interleaving strategy.

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