Abstract #4869

Can blood flow and artery patency alterations in medium-to-large arteries predict alteration in cognitive function?

Kaiyu Zhang¹, Zhensen Chen², Li Chen¹, Gador Canton¹, Duygu Baylam Geleri¹, Kristi Pimentel¹, Niranjan Balu¹, Thomas Hatsukami¹, and Chun Yuan¹

¹Vascular Imaging Lab and BioMolecular Imaging Center, Department of Radiology, University of Washington, Seattle, WA, United States, ²Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Association between brain tissue level perfusion and cognitive decline has been previously documented. However, contribution of blood flow and artery patency in medium-to-large arteries and its relation to tissue level perfusion and cognition remain unclear. In this study, 3D-TOF, ASL, and SNAP, an MRA technique sensitive to slow blood flow, were acquired at baseline and 12-months follow-up. A vascular map construction software was used to measure changes in medium-to-large arterial features. Changes in SNAP artery length and branch number during follow-up were significantly associated with changes in cognitive function, while no such association was found with ASL tissue level perfusion.

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