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Abstract #4869

Can blood flow and artery patency alterations in medium-to-large arteries predict alteration in cognitive function?

Kaiyu Zhang1, Zhensen Chen2, Li Chen1, Gador Canton1, Duygu Baylam Geleri1, Kristi Pimentel1, Niranjan Balu1, Thomas Hatsukami1, and Chun Yuan1
1Vascular Imaging Lab and BioMolecular Imaging Center, Department of Radiology, University of Washington, Seattle, WA, United States, 2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China


Association between brain tissue level perfusion and cognitive decline has been previously documented. However, contribution of blood flow and artery patency in medium-to-large arteries and its relation to tissue level perfusion and cognition remain unclear. In this study, 3D-TOF, ASL, and SNAP, an MRA technique sensitive to slow blood flow, were acquired at baseline and 12-months follow-up. A vascular map construction software was used to measure changes in medium-to-large arterial features. Changes in SNAP artery length and branch number during follow-up were significantly associated with changes in cognitive function, while no such association was found with ASL tissue level perfusion.

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