Cerebral blood flow (CBF) in periventricular white matter (PVWM) may provide a mechanistically specific biomarker of cerebral small vessel disease. We compared the reliability of PVWM CBF obtained from arterial spin labeling MRI acquired twice separated by a week, using different protocols involving standard, long labeling duration, single and multiple inflow saturation (MIS), and level of background suppression (BS), in young healthy participants. The MIS protocol with 99% BS significantly improved the temporal signal to noise ratio of the acquisition, with a subtle improvement of intersession-reliability. Reliability of PVWM CBF was of the same order as other conventional regions of interest.
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