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Abstract #4875

Reliability of Periventricular White Matter Cerebral Blood Flow using Different ASL protocols

Shokufeh Sadaghiani1, William Tackett1, M. Dylan Tisdall2, John A. Detre1, and Sudipto Dolui2
1Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States


Cerebral blood flow (CBF) in periventricular white matter (PVWM) may provide a mechanistically specific biomarker of cerebral small vessel disease. We compared the reliability of PVWM CBF obtained from arterial spin labeling MRI acquired twice separated by a week, using different protocols involving standard, long labeling duration, single and multiple inflow saturation (MIS), and level of background suppression (BS), in young healthy participants. The MIS protocol with 99% BS significantly improved the temporal signal to noise ratio of the acquisition, with a subtle improvement of intersession-reliability. Reliability of PVWM CBF was of the same order as other conventional regions of interest.

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