The basal forebrain (BF) has a known regulatory role in the cholinergic vasodilatory system, increasing cerebral blood flow (CBF) in the cerebral cortex using animal studies. However, parallel human studies have never been performed. Thirty-three young adults and 27 older adults were tested for the aged-related changes in arterial transit time (ATT) and CBF, which were measured using arterial spin labeling (ASL). We observed the age-related CBF and ATT changes in the basal forebrain and other brain regions, which provide a foundation for investigating the regulatory role of the basal forebrain on the cholinergic vasodilatory system.
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