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Abstract #4874

Potential regulation of cerebral blood flow by the basal forebrain

Zongpai Zhang1, Elizabeth Riley2, Adam K. Anderson2, Eve D. DeRosa2, and Weiying Dai1
1Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 2Department of Psychology, Cornell University, Ithaca, NY, United States


The basal forebrain (BF) has a known regulatory role in the cholinergic vasodilatory system, increasing cerebral blood flow (CBF) in the cerebral cortex using animal studies. However, parallel human studies have never been performed. Thirty-three young adults and 27 older adults were tested for the aged-related changes in arterial transit time (ATT) and CBF, which were measured using arterial spin labeling (ASL). We observed the age-related CBF and ATT changes in the basal forebrain and other brain regions, which provide a foundation for investigating the regulatory role of the basal forebrain on the cholinergic vasodilatory system.

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