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Abstract #4881

Customized whole-brain covering GRASE in multi-delay pCASL for distinct contrasts and adequate SNRs in hemodynamic parameter mappings

Yichen Hu1, Qing Wei2, Zhongyang Zhou2, Junpu Hu2, Jun Xie2, and Jian Xu1
1UIH America, Inc., Houston, TX, United States, 2United Imaging Healthcare, Shanghai, China


We report that manipulation of GRASE readout with SORT view-ordering in multi-delay ASL on either gradient echo trains for adjusted spatial resolutions or FSE train for modulated T2-blurring can significantly alter the perfusion hemodynamic parameter mapping contrasts among tissues and among cerebral lobes under different pathways of blood circulation, and can meanwhile regulate the SNRs of the maps. Among the performed GRASE designs, the readout with moderate spatial resolution and segmented kz is recommended for sharp GM/WM contrasts in CBF and ATT maps in conjunction with distinct contrast between anterior and posterior circulations in the ATT map, with adequate SNRs.

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