Abstract #4885

Blood-brain barrier permeability in response to caffeine challenge

Zixuan Lin¹, Dengrong Jiang¹, Peiying Liu^1,2, Abhay Moghekar³, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Caffeine is known to alter brain physiology by acting as an adenosine antagonist, but its effect on the BBB permeability to water is not fully elucidated. In this study, we utilized water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI to investigate the change of BBB permeability after caffeine challenge in young healthy adults. Results showed that after caffeine ingestion, water extraction across BBB increased as global cerebral blood flow decreased, while the BBB permeability to water remained unchanged, indicating a relative stable BBB function in response to caffeine challenge, which can be important for normal brain function.

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