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Abstract #4886

Augmented Perfusion Quantified by MRI Depends on Collateral Recruitment in Middle Cerebral Artery Occlusion: A Pilot Study

Mira Liu1, Niloufar Saadat1, Yong Jeong1, Steven Roth2, Marek Niekrasz1, Gregory Christoforidis1, and Timothy Carroll1
1University of Chicago, Chicago, IL, United States, 2University of Illinois, Chicago, IL, United States


We have developed an experimental model and quantitative MRI biomarkers to quantify the effects of therapeutic intervention to enhance collateralization in acute stroke. We performed controlled experiments in a pre-clinical canine model of ischemic stroke and use quantitative cerebral MR perfusion with DSC, intravoxel incoherent motion (IVIM), and neutron capture microsphere deposition, x-ray angiography for collateralization, and MR diffusion imaging for infarction to demonstrate a significant increase in perfusion and decrease in infarct growth in the hyperacute phase of an ischemic stroke.

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