We have developed an experimental model and quantitative MRI biomarkers to quantify the effects of therapeutic intervention to enhance collateralization in acute stroke. We performed controlled experiments in a pre-clinical canine model of ischemic stroke and use quantitative cerebral MR perfusion with DSC, intravoxel incoherent motion (IVIM), and neutron capture microsphere deposition, x-ray angiography for collateralization, and MR diffusion imaging for infarction to demonstrate a significant increase in perfusion and decrease in infarct growth in the hyperacute phase of an ischemic stroke.
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