Using time of flight magnetic resonance angiography, we explored how local variations in cerebral arterial morphology are related to cerebral blood flow (CBF) and cortical thickness (CT). We observed a significant, negative relationship between the proximity of a region of interest to an artery and CBF and CT such that regions proximal to large arteries have higher CBF and CT. These results highlight the importance of considering underlying cerebral vasculature when studying the human brain using MRI as it can lead to significant biases in commonly employed metrics.
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