Imaging Ascending Thoracic Aortic Aneurysm Wall Stretch: A Comparison to Biaxial Mechanical Testing
Huiming Dong1, Henrik Haraldsson1, Joseph Leach1, Ang Zhou1, Megan Ballweber1, Chengcheng Zhu2, Yue Xuan3, Zhongjie Wang3, Michael Hope1, Liang Ge3, Frederick H. Epstein4, David Saloner1, Elaine Tseng3, and Dimitrios Mitsouras1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States, 3Department of Surgery, University of California, San Francisco, San Francisco, CA, United States, 4Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States
Ascending thoracic aortic aneurysm (aTAA) can result in life-threatening rupture or dissection. Displacement encoding with stimulated echoes (DENSE) is a non-invasive phase-contrast MRI technique that can measure aTAA wall deformation during the cardiac cycle. This study investigated DENSE-derived aTAA wall stretch in patients and found that the ratio between aTAA stretch and descending aorta stretch was different in patients who met surgical repair criteria from those who did not. Moreover, mechanical properties of aTAA specimens from patients who underwent surgery correlated significantly with in vivo DENSE measurements. Our findings suggest DENSE as a potential imaging marker for understanding aTAA progression.
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