Abstract #4889

Imaging Ascending Thoracic Aortic Aneurysm Wall Stretch: A Comparison to Biaxial Mechanical Testing

Huiming Dong¹, Henrik Haraldsson¹, Joseph Leach¹, Ang Zhou¹, Megan Ballweber¹, Chengcheng Zhu², Yue Xuan³, Zhongjie Wang³, Michael Hope¹, Liang Ge³, Frederick H. Epstein⁴, David Saloner¹, Elaine Tseng³, and Dimitrios Mitsouras¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Department of Surgery, University of California, San Francisco, San Francisco, CA, United States, ⁴Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States

Synopsis

Ascending thoracic aortic aneurysm (aTAA) can result in life-threatening rupture or dissection. Displacement encoding with stimulated echoes (DENSE) is a non-invasive phase-contrast MRI technique that can measure aTAA wall deformation during the cardiac cycle. This study investigated DENSE-derived aTAA wall stretch in patients and found that the ratio between aTAA stretch and descending aorta stretch was different in patients who met surgical repair criteria from those who did not. Moreover, mechanical properties of aTAA specimens from patients who underwent surgery correlated significantly with in vivo DENSE measurements. Our findings suggest DENSE as a potential imaging marker for understanding aTAA progression.

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