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Abstract #4890

Predicting penumbral tissue death using intravoxel incoherent motion MRI in a canine large vessel occlusion model

Mohammed Salman Shazeeb1, Robert King1, Zeynep Vardar1, Josephine Kolstad1, Vania Anagnostakou1, Nils Henninger1, and Matthew Gounis1
1University of Massachusetts Medical School, Worcester, MA, United States


In acute ischemic stroke due to large vessel occlusion (LVO), information about the penumbral tissue can be vital in making decisions on how to treat ischemic stroke patients in the clinic. This study investigated the use of intravoxel incoherent motion (IVIM) MRI in a canine LVO model to quantify the perfusion information in penumbral tissue prior to infarction. The IVIM parameters were assessed to predict the onset of penumbral tissue death. Of the 3 IVIM parameters, f showed the best utility in predicting penumbral tissue death.

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