Abstract #4890

Predicting penumbral tissue death using intravoxel incoherent motion MRI in a canine large vessel occlusion model

Mohammed Salman Shazeeb¹, Robert King¹, Zeynep Vardar¹, Josephine Kolstad¹, Vania Anagnostakou¹, Nils Henninger¹, and Matthew Gounis¹

¹University of Massachusetts Medical School, Worcester, MA, United States

Synopsis

In acute ischemic stroke due to large vessel occlusion (LVO), information about the penumbral tissue can be vital in making decisions on how to treat ischemic stroke patients in the clinic. This study investigated the use of intravoxel incoherent motion (IVIM) MRI in a canine LVO model to quantify the perfusion information in penumbral tissue prior to infarction. The IVIM parameters were assessed to predict the onset of penumbral tissue death. Of the 3 IVIM parameters, f showed the best utility in predicting penumbral tissue death.

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