Abstract #4891

Hypertension is Associated with Intracranial Atherosclerotic Plaque Burden and Distribution: a MR Vessel Wall Imaging Study

Jiayu Xiao¹, Jae W Song², Steven Y Cen^1,3, Fang Wu⁴, Xiao Liu⁵, Tao Jiang⁵, Konrad H Schlick⁶, Debiao Li⁷, Shlee S Song⁶, Qi Yang⁵, and Zhaoyang Fan^1,8,9

¹Radiology, Keck School of Medicine, Los Angeles, CA, United States, ²Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, ³Neurology, Keck School of Medicine, Los Angeles, CA, United States, ⁴Radiology, Xuanwu Hospital, Beijing, China, ⁵Radiology, Beijing Chaoyang Hospital, Beijing, China, ⁶Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁷Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁸Radiation Oncology, Keck School of Medicine, Los Angeles, CA, United States, ⁹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

Synopsis

Hypertension is one of the most important modifiable risk factor for atherosclerosis. However, the association between blood pressure and intracranial plaque remains unclear. In this study, we investigated the impact of hypertension on intracranial plaque burden and distribution in 174 patients with recent ischemic stroke. Systolic blood pressure and diastolic blood pressure were independently associated with a higher total plaue burden as well as higher plaque counts at the proximal and junctional locations. These findings suggest hypertension may influence not only the count burden but also the distribution of intracranial plaque development.

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