Abstract #4891
Hypertension is Associated with Intracranial Atherosclerotic Plaque Burden and Distribution: a MR Vessel Wall Imaging Study
Jiayu Xiao1, Jae W Song2, Steven Y Cen1,3, Fang Wu4, Xiao Liu5, Tao Jiang5, Konrad H Schlick6, Debiao Li7, Shlee S Song6, Qi Yang5, and Zhaoyang Fan1,8,9
1Radiology, Keck School of Medicine, Los Angeles, CA, United States, 2Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, 3Neurology, Keck School of Medicine, Los Angeles, CA, United States, 4Radiology, Xuanwu Hospital, Beijing, China, 5Radiology, Beijing Chaoyang Hospital, Beijing, China, 6Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 7Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 8Radiation Oncology, Keck School of Medicine, Los Angeles, CA, United States, 9Biomedical Engineering, University of Southern California, Los Angeles, CA, United States
Synopsis
Hypertension is one of the most important modifiable risk factor for atherosclerosis. However, the association between blood pressure and intracranial plaque remains unclear. In this study, we investigated the impact of hypertension on intracranial plaque burden and distribution in 174 patients with recent ischemic stroke. Systolic blood pressure and diastolic blood pressure were independently associated with a higher total plaue burden as well as higher plaque counts at the proximal and junctional locations. These findings suggest hypertension may influence not only the count burden but also the distribution of intracranial plaque development.
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