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Abstract #4899

Dynamic 3D T1 MRI method for T1-based Quantification of DCE for the Measurements of kinetic Parameters on Carotid Atherosclerotic Plaques

Seong-Eun Kim1, John A Roberts1, J. Scott MacNally1, Mathew Alexander 1, Gerald S Treiman2,3, Hediyeh Baradaran1, and Dennis L Parker1
1UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Department of Surgery, University of Utah, Salt Lake City, UT, United States, 3VASLCHCS, Salt Lake City, UT, United States


This work introduced a reliable, comprehensive carotid DCE technique, including a high spatial and temporal resolution 3D dynamic T1 sequence and retrospective reconstruction methods to measure kinetic parameters on carotid atherosclerotic plaque. This technique can be used to evaluate the correlation between kinetic parameters and ischemic stroke. We believe that plaque kinetic parameters can be used in subsequent clinical trials as a changeable predictor of ischemic stroke risk. Clinicians could then use carotid DCE to monitor early response to medical therapy, and thereby improve detection and treatment of unstable carotid plaque and prevention of stroke.

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