Abstract #4900

On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arteriolar cerebral blood volume (CBVa)

Chunming Gu^1,2,3, Di Cao^1,2,3, Xinyuan Miao^2,3, Adrian G Paez^2,3, Jitong Cai¹, Yinghao Li^1,2,3, Wenbo Li^2,3, Jay J Pillai^4,5, Peter C.M. van Zijl^2,3, and Jun Hua^2,3

¹Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

The iVASO MRI is a noninvasive approach for quantitative mapping of CBVa in the brain. It was originally developed in the single-slice mode. Recently, CBVa measured by single-slice iVASO has been validated using histological markers of arteriolar blood vessels in a mouse model. Here, we demonstrate an optimized 3D iVASO MRI protocol with a 3D turbo-field-echo (TFE) readout and a whole-brain coverage. It showed consistent CBVa measures when compared to the original single-slice iVASO. In 3D-TFE-iVASO, the imaging slab volume did not show significant effects on the measured CBVa values. CBVa measured with 3D-TFE-iVASO showed reasonable intra-subject reproducibility.

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