Abstract #4900
On the optimization of 3D inflow-based vascular-space-occupancy (iVASO) MRI for the quantification of arteriolar cerebral blood volume (CBVa)
Chunming Gu1,2,3, Di Cao1,2,3, Xinyuan Miao2,3, Adrian G Paez2,3, Jitong Cai1, Yinghao Li1,2,3, Wenbo Li2,3, Jay J Pillai4,5, Peter C.M. van Zijl2,3, and Jun Hua2,3
1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Synopsis
The iVASO MRI is a noninvasive approach for quantitative mapping of CBVa in the brain. It was originally developed in the single-slice mode. Recently, CBVa measured by single-slice iVASO has been validated using histological markers of arteriolar blood vessels in a mouse model. Here, we demonstrate an optimized 3D iVASO MRI protocol with a 3D turbo-field-echo (TFE) readout and a whole-brain coverage. It showed consistent CBVa measures when compared to the original single-slice iVASO. In 3D-TFE-iVASO, the imaging slab volume did not show significant effects on the measured CBVa values. CBVa measured with 3D-TFE-iVASO showed reasonable intra-subject reproducibility.
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