Abstract #4901

Evaluation of a Novel Manganese-Based Contrast Agent for Cardiac MRI in the Setting of Myocardial Ischemia-Reperfusion

Benjamin Pryor Bonner^1,2,3, Jaume Coll-Font^1,2,4, Salva Yurista^1,2,4, Anna Foster^1,2, Robert Eder^1,2, Shi Chen^1,2, Peter Caravan^2,4, Eric Gale^2,4, and Christopher Nguyen^1,2,4,5

¹Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ³Louisiana State University Health Sciences Center, New Orleans, New Orleans, LA, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Division of Health Science Technology, Harvard-Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Cardiac MRI a powerful imaging modality to assess cardiac anatomy and function, and its utility can be greatly enhanced with the use of contrast agents. Conventional contrast agents are nephrotoxic which limits their utility. We evaluate a novel contrast agent which is safe for use in renal dysfunction. We compare its performance against that of a conventional agent a porcine model of ischemia-reperfusion. This novel contrast agent demonstrates equivalent performance in assessing myocardial fibrotic scars, indicating its potential clinical use in the workout of cardiac patients with renal impairment.

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