Saturation based velocity-selective ASL (VSASL) was recently investigated for acetazolamide challenge and notably lower cerebrovascular reactivity (CVR) was observed when comparing to PET results. Here we compared the performance of velocity-selective inversion (VSI) prepared ASL and pseudo-continuous ASL in response to the hypercapnia challenge for CO2-induced CVR quantification with phase-contrast MRI as a global reference. VSI-ASL could underestimate the regional CVR when the trailing edge of the labeled bolus arrive before the PLD as the CBF during hypercapnia would be underestimated. In contrast, PCASL could overestimate CVR in areas with long ATT as the baseline CBF would be underestimated.
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