Abstract #4908

MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE): A Simulation Study for Accuracy Validation

Zhehao Hu^1,2, Nan Wang³, Anthony Christodoulou^2,3, Mark Shiroishi¹, Gabriel Zada⁴, Debiao Li^2,3, and Zhaoyang Fan^1,5,6

¹Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁵Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁶Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

Synopsis

MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE) technique is recently developed and has the potential to provide DCE- and leakage-corrected DSC-MRI parameters simultaneously with one 7.6-minute scan and a single-dose contrast injection. However, it remains a practical challenge to validate the technique against their respective references with repeated contrast injections in separate days. In this work, we perform a numerical simulation study to validate the accuracy of MT-DICE in the estimation of permeability and leakage-corrected perfusion metrics.

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