Abstract #4908
MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE): A Simulation Study for Accuracy Validation
Zhehao Hu1,2, Nan Wang3, Anthony Christodoulou2,3, Mark Shiroishi1, Gabriel Zada4, Debiao Li2,3, and Zhaoyang Fan1,5,6
1Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States
Synopsis
MR Multitasking-based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE) technique is recently developed and has the potential to provide DCE- and leakage-corrected DSC-MRI parameters simultaneously with one 7.6-minute scan and a single-dose contrast injection. However, it remains a practical challenge to validate the technique against their respective references with repeated contrast injections in separate days. In this work, we perform a numerical simulation study to validate the accuracy of MT-DICE in the estimation of permeability and leakage-corrected perfusion metrics.
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