Abstract #4909

Cerebral Blood Flow Patterns in Term and Premature Neonates measured at Term-Equivalent-Age: a PCASL study

Antonio Maria Chiarelli¹, Eleonora Piccirilli¹, Carlo Sestieri¹, Daniele Mascali¹, Emma Biondetti¹, Antonio Ferretti¹, Richard Wise¹, and Massimo Caulo^1,2

¹Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti Pescara, Chieti, Italy, ²Department of Radiology, SS. Annunziata University Hospital, Chieti, Italy

Synopsis

During the perinatal period the brain undergoes extensive development, including increasing brain perfusion and metabolism. More rapidly modifying brain areas may be more sensitive to insults and transient hypoxic states. We performed PCASL on 115 infants at term equivalent age (TEA) with variable gestational age at birth. Insular-subcortical and somato-motor regions exhibited high grey matter CBF_(GM) in both term and preterm newborns. However, premature neonates showed a redistribution of perfusion compared to term infants, with somato-motor regions showing even higher CBF_GM. These results suggest that insular-subcortical and somato-motor regions may reflect brain health and development at TEA.

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