Abstract #4912

3D Inversion recovery-FLASH and myocardial perfusion MRI imaging in a sheep model of myocardial infarction

Steven KS Cho¹, Jack RT Darby², Georgia K Williams³, Catherine G Dimasi², Stacey L Holman², Joseph B Selvanayagam⁴, Christopher K Macgowan⁵, Janna L Morrison², and Mike Seed⁶

¹Physiology, University of Toronto, North York, ON, Canada, ²Early Origins of Adult Health Research Group, Health and Biomedical Innovation, University of South Australia, Adelaide, Australia, ³South Australian Health & Medical Research Institute, Preclinical, Imaging & Research Laboratories, Adelaide, Australia, ⁴Cardiac Imaging Research Group, Department of Heart Health, South Australian Health and Medical Research Institute, Flinders University, Adelaide, Australia, ⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁶Division of Cardiology, The Hospital for Sick Children, Toronto, ON, Canada

Synopsis

We investigated the accuracy of cardiac MRI for detecting myocardial infarction (MI) induced by coronary artery ligation surgery in a sheep model. 3D-inversion recovery (IR) FLASH sequence and first-pass perfusion imaging was feasible and provided accurate information about the size and location of MI immediately after surgery and at 15-day follow-up. The IR-FLASH sequence detected infarcts (91.2% sensitivity, 99.9% specificity) compared with gold-standard pathology staining findings. This may prove useful for preclinical research in which it is important to document the natural history of myocardial injury, such as in studies investigating interventions aimed at mitigating the long-term impact of MI.

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