Abstract #4913

Evaluation of Sex and Age Differences in Myocardial Microstructure using Cardiac Diffusion Tensor Imaging

Shi Chen¹, Jaume Coll-Font^1,2,3, Robert Eder¹, Anna Foster ¹, Salva Yurista ^1,2,3, and Christopher T. Nguyen^1,2,3,4

¹Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Division of Health Science Technology, Harvard-Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Sexes and ages are known factors that contribute to cardiovascular pathophysiological variances and prognosis. This study used in-vivo cardiac diffusion tensor MRI (DT-MRI) to characterize how myocardial microstructure differs across sexes and ages. To that purpose, thirty healthy volunteers (14 female) were imaged with in-vivo cardiac DT-MRI and common DT-MRI parameters (MD, FA, HAT, E2A) were computed within the left ventricle (LV). No significant sex-related differences (11%, 9%, 3%, 9% respectively for MD, FA, HAT, E2A at septal regions) or age-related correlations were found. Taken together, sex and age had no effects on the quantification of in-vivo cardiac DT-MRI parameters.

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