Abstract #4920

Preservation of Human Hearts for Transplantation: Comparison of Metabolic Indicators after Conventional and Temperature Controlled Storage

Gaurav Sharma¹, Ryan J. Vela², LaShondra Powell², Stanislaw Deja^3,4, Monika Mizerska³, Michael E. Jessen², Shawn C. Burgess^3,5, Craig R. Malloy^1,6,7, and Matthias Peltz²

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Preservation of human hearts for transplantation is important to optimize outcomes. Standard ischemic cooling methods are intended to preserve high energy phosphates but risk tissue damage due to freezing; an alternative with precise temperature control has emerged as an option. The efficacy of this technique in preserving high energy phosphates and other metabolites has not been examined. We compared conventional cold storage to a commercial device with precise temperature control for preservation of human hearts not suitable for transplant. There were no significant differences in high energy phosphates or other metabolites using precise temperature control compared to conventional cold storage.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.