Abstract #4920
Preservation of Human Hearts for Transplantation: Comparison of Metabolic Indicators after Conventional and Temperature Controlled Storage
Gaurav Sharma1, Ryan J. Vela2, LaShondra Powell2, Stanislaw Deja3,4, Monika Mizerska3, Michael E. Jessen2, Shawn C. Burgess3,5, Craig R. Malloy1,6,7, and Matthias Peltz2
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 6Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Synopsis
Preservation of human hearts for transplantation is important to optimize outcomes. Standard ischemic cooling methods are intended to preserve high energy phosphates but risk tissue damage due to freezing; an alternative with precise temperature control has emerged as an option. The efficacy of this technique in preserving high energy phosphates and other metabolites has not been examined. We compared conventional cold storage to a commercial device with precise temperature control for preservation of human hearts not suitable for transplant. There were no significant differences in high energy phosphates or other metabolites using precise temperature control compared to conventional cold storage.
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