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Abstract #4921

Confirming conduction defect in fatty acid oxidation compromised heart using MRI strain imaging

El-Sayed H Ibrahim1, Jason Jarzembowski1, and Suresh Kumar1
1Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Healthy heart is a metabolically dynamic organ requiring large energy resource, and fatty acid oxidation (FAO) pathway predominantly supports this energy demands. Disorders of FAO pathways could range from mild and manageable to severe and life-threatening. In this study, we use MRI to evaluate the heart function in mitochondrial trifunctional protein (MTP) mutant rats, where clinical symptoms of this disorder overlap with other less severe FAO deficiencies and are often misdiagnosed. The results showed that MRI strain imaging revealed subclinical cardiac dysfunction in the MTP mutant rats with the degree of strain reduction depending on strain direction and regional location.

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