Abstract #4939

Time-Dependent Diffusion Tensor Imaging and Modeling of Aging Muscles: Correlations to Muscle Strain, Histology and Physical Assessment

Vadim Malis¹, Usha Sinha², Edward Smitaman¹, Jed Keenan Obra³, Henning T Langer³, Agata A Mossakowski³, Keith Baar³, and Shantanu Sinha¹

¹Radiology, UC San Diego, San Diego, CA, United States, ²Physics, San Diego State University, San Diego, CA, United States, ³Physiology and Membrane Biology, UC Davis, Davis, CA, United States

Synopsis

Diffusion modeling (RPBM) of the time dependence of the skeletal muscle diffusion eigenvalues was applied to probe tissue changes with age. λ₂ (TM=30 ms) was significantly lower in seniors; permeability and the residence time from RPBM were significantly positively correlated with grip size and 200 m walk. Significant negative correlations of λ₁ and λ₂ to age and to physical λ₂ / λ₃ to collagen matrix angle and to systolic/diastolic blood pressure were seen. λ₂ and λ₃ were significantly positively correlated to the projection of the strain on the diffusion eigenvector corresponding to the secondary eigenvalue.

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