Diffusion modeling (RPBM) of the time dependence of the skeletal muscle diffusion eigenvalues was applied to probe tissue changes with age. λ2 (TM=30 ms) was significantly lower in seniors; permeability and the residence time from RPBM were significantly positively correlated with grip size and 200 m walk. Significant negative correlations of λ1 and λ2 to age and to physical λ2 / λ3 to collagen matrix angle and to systolic/diastolic blood pressure were seen. λ2 and λ3 were significantly positively correlated to the projection of the strain on the diffusion eigenvector corresponding to the secondary eigenvalue.
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