MRI-based compositional imaging of cartilage has higher sensitivity to detect early changes in osteoarthritis. The osteochondral junction (OCJ) is of particular interest since it has been associated with early changes and progression of cartilage degeneration. However, conventional MRI sequences cannot differentiate with high contrast the OCJ region for quantification. Here we present quantification of T1, T1rho, T2*, and macromolecular fraction (MMF) of deep and superficial layers knee cartilage using 3D ultrashort echo time (UTE) MRI cones sequences and correlate the values from the OCJ with the degree of cartilage degeneration according to the MRI Osteoarthritis Knee Cartilage Score (MOAKS).
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