4D MRI and external motion capture systems were utilized to track unconstrained movement of wrist carpal bones. Using slab-to-volume registration of dynamic MRI to static MRI reference images, wrist kinematic profiles for 19 healthy subjects were computed and compared to gold-standard motion analysis metrics during ulnar/radial deviation and flexion/extension motions. The agreement of kinematic measures derived using the intrinsic (i.e. carpal bone volume) MRI-based approach and external (sensor-based) motion capture methods provided validation of the deployed MRI-based kinematic profiling methodology.
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