Abstract #4945

**Correlation between T1, T1rho, T2*, MMF, and Biomechanics in Human Interspinous Ligament Using quantitative Ultrashort Echo Time (UTE) MRI**

Alecio F. Lombardi^1,2, Saeed Jerban¹, Ya-Jun Ma¹, Micah Blais³, Robert K. Eastlack³, Gregory M. Mundis Jr.³, Jiang M. Du¹, Eric Y. Chang^1,2, and Bahar K. Shahidi⁴

¹Department of Radiology, University of California, San Diego, CA, United States, ²Radiology Service, Veterans Affairs, San Diego Healthcare System, San Diego, CA, United States, ³Department of Orthopedic Surgery, Scripps Clinic, San Diego, CA, United States, ⁴Department of Orthopedic Surgery, University of California, San Diego, CA, United States

Synopsis

This study aimed to quantify T1, T1rho, T2*, and MMF values of the human interspinous ligament using 3D ultrashort echo time (UTE) cones MRI and correlate them with biomechanical properties. We found a significant negative correlation between T1 and elastic modulus; significant moderate to strong negative correlations between T1rho and both tensile stress and maximum load; and significant moderate to strong positive correlations between MMF and both tensile stress and maximum load. There was an overall trend towards negative correlation between T2* and biomechanical properties.

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