Abstract #4945
Correlation between T1, T1rho, T2*, MMF, and Biomechanics in Human Interspinous Ligament Using quantitative Ultrashort Echo Time (UTE) MRI
Alecio F. Lombardi1,2, Saeed Jerban1, Ya-Jun Ma1, Micah Blais3, Robert K. Eastlack3, Gregory M. Mundis Jr.3, Jiang M. Du1, Eric Y. Chang1,2, and Bahar K. Shahidi4
1Department of Radiology, University of California, San Diego, CA, United States, 2Radiology Service, Veterans Affairs, San Diego Healthcare System, San Diego, CA, United States, 3Department of Orthopedic Surgery, Scripps Clinic, San Diego, CA, United States, 4Department of Orthopedic Surgery, University of California, San Diego, CA, United States
Synopsis
This study aimed to quantify T1, T1rho, T2*, and MMF values of the human interspinous ligament using 3D ultrashort echo time (UTE) cones MRI and correlate them with biomechanical properties. We found a significant negative correlation between T1 and elastic modulus; significant moderate to strong negative correlations between T1rho and both tensile stress and maximum load; and significant moderate to strong positive correlations between MMF and both tensile stress and maximum load. There was an overall trend towards negative correlation between T2* and biomechanical properties.
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