Abstract #4946

Single and Multi-channel evaluations of factors that affect cartilage T1ρ and T2 quantification

zhiyuan zhang^1,2,3, Jeehun Kim^2,3,4, Richard Lartey^2,3, Carl S. Winalski^2,3,5, and Xiaojuan Li^2,3,5

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ³Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁵Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

MR T1ρ and T2 have been suggested as promising imaging markers for detecting early cartilage degeneration in osteoarthritis¹. However, one hurdle of applying such quantitative MRI to large clinical trials and clinical practice is the lack of standardization of data acquisition and processing. In this study, we evaluated multiple factors that affect cartilage T1ρ and T2 quantification including maximum TE, number of echoes, SNR, and fitting methods for single and multi-channel situations with simulations, phantoms and human data. Such evaluations will help to provide useful guidance in standardizing data acquisition and processing for cartilage T1ρ and T2 imaging.

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